- 1860
- Founder, Nezu Kaichirō (Sr.) was born in Yamanashi.
- 1896
- Kaichirō moved his base to Tokyo
- 1906
- Bought land in Aoyama (current location of the museum). Purchased a famous "Writing Box known as Hana-no-Shirakawa" at an auction of Hirase family collection.
- 1938
- Began publication of the museum collection named Seizanso seisho, completed in 1943.
- 1940
- Kaichirō passed away in January at the age of 80. According to his will, Nezu Museum Foundation was established in November by his son, Kaichirō Jr.

- 1941
- The first exhibition was held at Nezu's residence in November.

- 1944
- Museum suspended exhibitions due to intensifying war. Collection was evacuated to the suburb.
- 1945
- Nezu's residence and garden was burned down in an air raid.
- 1946
- Kaichirō Jr. restarted the exhibitions at a temporary building.
- 1954
- New exhibition hall was completed.

- 1959
- Kaichirō Jr. inaugurated as Museum Director.

- 1981
- Kaichirō Jr. was shifted to Chairman of the Board of Trustees of the museum.
- 1990
- New exhibition hall was completed.

- 2000
- Nezu Kōichi, son of Kaichirō Jr., inaugurated as Museum Director.
- 2002
- Kaichirō Jr. passed away. Kōichi took the position of Chairman of the Board of Trustees.
- 2006
- Museum decided to close for a large-scale renovation.
- 2009
- Reopened the new museum building